Senior Bioinformatician – Transcriptomics
About Somite.ai
Somite.ai is a venture-backed company transforming stem cell biology with AI. We recently raised over $47 million in a Series A funding round, bringing our total funding to about $60 million. Our mission is to transform regenerative medicine using our AI-driven DeltaStem platform. Just as LLMs revolutionized human language, we’re decoding the language of cells—how they communicate and decide their fate—using vast amounts of in-house generated data. Our AI models enable precise control over cell behavior, unlocking the potential to engineer therapies for diseases like diabetes, neurodegenerative diseases, and muscular dystrophies. Our platform, DeltaStem, accelerates therapy creation and continually improves through data-driven insights.
Founded by Dr. Micha Breakstone, a serial AI entrepreneur from MIT, and three Harvard Medical School professors, including the Chair of Genetics, Somite.ai is at the forefront of a new era in healthcare.
Location: Boston
Click the following links to learn more about Somite:
https://x.com/SomiteAi/status/1922284999891472808
Click the following link to Apply:
https://jobs.ashbyhq.com/somite-ai?utm_source=LinkedIn+Manual+Posting
About the Role:
We seek a skilled Computational Bioinformatician to lead the design and execution of analysis pipelines for large-scale transcriptomic datasets. You’ll be responsible for preprocessing, quality control, and biological interpretation of sequencing data, contributing to the development of novel sequencing protocols and technologies in close collaboration with wet lab scientists, computational biologists and machine learning researchers to support Somite’s therapeutic programs.
This is a hands-on, data-centric role ideal for someone who thrives in a fast-paced, interdisciplinary environment and wants to help build transformative cell therapy technologies from the ground up.
Responsibilities:
● Build, maintain, and run robust, reproducible pipelines for single-cell and bulk RNA-seq data (QC, alignment, quantification, normalization, clustering, annotation, etc.).
● Apply standard and advanced analyses using tools like Scanpy, Seurat, and R/Bioconductor packages.
● Process and interpret data from state-of-the-art single-cell transcriptomic and multiomic platforms, alongside new in-house protocols being developed to enable innovative microbiological sequencing workflows.
● Collaborate with wet lab scientists to support experimental design and data interpretation.
● Mentor and foster collaboration and knowledge sharing across disciplines.
● Help design and validate cutting-edge protocols for novel transcriptomic technologies, integrating new experimental modalities with bioinformatics pipeline.
Qualifications:
● PhD in Bioinformatics, Genomics, Computational Biology, or a related field. Equivalent industry experience is also welcome.
● 3+ years of hands-on experience analyzing large-scale single-cell or bulk transcriptomic datasets.
● Proficiency with common genomics tools: SAMtools, STAR/STARsolo, Bowtie, Tophat, HTSeq, Clustal, bash scripting, etc.
● Strong command of Scanpy or Seurat
Demonstrated fluency in Nextflow/Snakemake and workflow reproducibility principles.
● Strong R and/or Python programming skills.
● Excellent organizational and documentation habits. Strong programming skills and experience developing robust products, preferably in Python
● Passion for data-driven biology and its potential to transform healthcare.
Preferred Qualifications:
● Experience working in a quantitative lab or with biotech/pharma pipelines.
● Experience working in a fast-paced startup or interdisciplinary team.
● The opportunity to contribute to platform technologies with real-world therapeutic impact.
● Experience working at the interface of technology development and data analysis, particularly involving novel molecular biology or sequencing techniques.
Click the following link to Apply:
https://jobs.ashbyhq.com/somite-ai?utm_source=LinkedIn+Manual+Posting
What We Offer:
● A mission-driven team reshaping healthcare through innovation in AI and cellular engineering - with the potential to significantly impact the lives of millions.
● The opportunity to contribute to platform technologies with real-world therapeutic impact.
● Work alongside a talented, collaborative, and passionate team at the forefront of AI and cellular biology.
● Contribute to the development of groundbreaking therapies that address significant unmet medical needs.
● Enjoy a competitive salary, equity and benefits package, including flexible work options.
Exceptional candidates who demonstrate outstanding capabilities and potential will be considered, even if they do not meet every qualification listed.
Join and help us unlock the full potential of AI for the benefit of human health.
